Trulicity vs Ozempic: How These GLP-1s Compare
Both are weekly GLP-1 injections for diabetes, but they differ in weight effect. The honest comparison.
The short answer
Trulicity (dulaglutide) and Ozempic (semaglutide) are both once-weekly GLP-1 injections approved for type 2 diabetes. They are not the same drug. For weight, semaglutide generally produces more average weight loss than dulaglutide, which is one reason semaglutide (as Wegovy) is also approved specifically for weight management while Trulicity is not.
Quick comparison
| Feature | Trulicity | Ozempic |
|---|---|---|
| Active ingredient | Dulaglutide | Semaglutide |
| Maker | Eli Lilly | Novo Nordisk |
| FDA-approved for | Type 2 diabetes | Type 2 diabetes |
| How it is taken | Weekly injection | Weekly injection |
| Weight effect | Generally less average weight loss | Generally more average weight loss |
| At New Hope Weight Loss | Not offered | Brand not offered; compounded semaglutide available, not FDA-approved or brand-identical |
How they differ
Both improve blood sugar and can support some weight loss, but head-to-head and across trials, semaglutide tends to drive more weight reduction. Dosing, tolerability, and individual response vary. Trulicity is a diabetes medication; the weight-specific approval belongs to semaglutide (Wegovy) and tirzepatide (Zepbound).
Ready to start?
$199 Skeptics' Trial, see if it works for you
One-time $199 trial with physician evaluation and, only if a prescription is approved and the dispensing pharmacy can fulfill it for the patient's location, one month of compounded semaglutide; the pharmacy confirms packaging and shipping details before fulfillment. No long-term commitment. Standard care starts with a $119 physician review; medication is separate, and compounded semaglutide programs start at $166/month.
Start the 30-day trialHow to choose
If diabetes control is the main goal, that is your physician's call based on your full picture. If weight is the focus, the medications with weight-specific evidence and approval are usually the starting point. A clinician weighs effectiveness, tolerability, cost, and your conditions.
How this relates to what we offer
We do not dispense Trulicity or Ozempic. The dispensing pharmacy label identifies the compounded preparation as semaglutide or tirzepatide. It is a different product from FDA-approved brands, is not FDA-approved or brand-identical, and results vary.
What you can start today at New Hope Weight Loss
After a one-time $119 medical review with Dr. Sharma, eligible patients begin physician-supervised compounded semaglutide from $166 a month or compounded tirzepatide from $233 a month, with a $199 one-month Skeptics' Trial. Compounded semaglutide and tirzepatide are not FDA-approved or brand-identical and have not undergone FDA premarket review for safety, effectiveness, or quality. Results vary. Any prescription depends on individualized medical review and lawful pharmacy fulfillment for the patient's location. In person in Orange County and by telehealth for eligible patients in California.
Frequently asked questions
Is Ozempic better than Trulicity for weight loss?
For weight, semaglutide (Ozempic) generally produces more average weight loss than dulaglutide (Trulicity). Semaglutide also has a weight-specific approval (Wegovy); Trulicity is a diabetes medication. A physician weighs your full picture.
Are Trulicity and Ozempic the same?
No. Trulicity is dulaglutide; Ozempic is semaglutide. Both are weekly GLP-1 injections approved for type 2 diabetes, but they are different molecules.
Is Trulicity approved for weight loss?
Trulicity is approved for type 2 diabetes, not specifically for weight loss. The weight-specific approvals belong to semaglutide (Wegovy) and tirzepatide (Zepbound).
Which has fewer side effects?
Both are mostly gastrointestinal and usually transient. Individual tolerance varies, so a physician helps you weigh the options.
Does New Hope offer Trulicity?
No. We offer physician-supervised compounded semaglutide and tirzepatide (not FDA-approved or brand-identical) after a $119 review with Dr. Sharma.
This article is informational only and not medical advice. Speak with a licensed physician before starting or changing any GLP-1 therapy. Individual results vary. New Hope Weight Loss is a physician-supervised medical weight loss clinic in Costa Mesa, CA. Eligibility for treatment is determined during the medical consultation. Compounded semaglutide and compounded tirzepatide are not the same products as Wegovy®, Ozempic®, Mounjaro®, or Zepbound®.